First seen by our source: 3 hours ago
Postdoctoral Researcher
@ Synth-Med Biotechnology Inc.
Toronto, Ontario
Overview
Synth-Med Biotechnology Inc. is hiring a full-time postdoctoral researcher to work with Dr. Craig Simmons' lab on in vitro blood-brain barrier models for CNS-directed enzyme replacement therapy and nanomedicine. The work covers building and running Transwell BBB models with hiPSC-derived cells, transport and permeability studies, and data analysis for preclinical programs. The posting states the role is based in the Simmons Lab in Toronto and includes mentoring students.
Responsibilities:
- Build and validate Transwell BBB models with hiPSC-derived cells
- Run barrier integrity and permeability assays
- Design and execute transport studies on enzyme and nanoparticle constructs
- Analyze and present data, contribute to reports and publications
- Mentor graduate and undergraduate students
Requirements summary:
- PhD in biomedical engineering, cell biology, neuroscience or pharmacology
- Hands-on Transwell BBB model experience
- Independent hiPSC culture experience
- Strong quantitative data analysis
- Peer-reviewed publication record
Tools & skills
Source and dates
Source type not verified · apify-linkedin
- Employer posting date
- Not provided
- First seen by our source
- 2026-11-14
- Source record updated
- 2026-11-14
These dates describe the source record, not a live verification that the employer is still hiring. Check the original posting.
Job details
| Seniority | Entry level |
| Department | Research & science |
| Hours per week | 40 (estimated) |
| Travel | air: minimal · ground: none |
| Work setting | Laboratory |
| Position | Sitting and standing |
| Physical demands | physical low · computer moderate |
| Education | Doctorate (required) |
| Fields of study | biomedical engineering, cell biology, neuroscience, pharmacology |
Summary and details written by AI from the posting; the employer’s posting is the authority.
Synth-Med Biotechnology Inc.
| Field | Value |
|---|---|
| Open jobs on Jobsy | 1 |
The position
Synth-Med Biotechnology Inc. is hiring a postdoctoral fellow to work in collaboration with Dr. Craig
Simmon’s lab on in vitro blood–brain barrier (BBB) models supporting Synth-Med’s CNS-directed
enzyme replacement therapy (ERT) and nanomedicine programs for lysosomal storage disorders.
The successful candidate you will be supporting our pre-clinical in-vitro testing of BBB crossing nano
carriers and help unveiling mechanistic processes of the technology.
This is a joint academic–industry role. You will be based in the Simmons Lab with access to its
microphysiological systems and stem cell infrastructure, and you will work closely with the Synth-Med
R&D team on program timelines and data packages.
What you'll do
• Establish, validate, and maintain Transwell BBB models, including hiPSC-derived brain microvascular
endothelial cells in mono- and co-culture with astrocytes, pericytes, and/or neurons
• Run barrier integrity and permeability assays (TEER, paracellular tracer flux, immunostaining for
junctional and transporter markers) and set acceptance criteria for study readouts
• Design and execute transport studies on enzyme conjugates, shuttle-peptide and single-domain
antibody constructs, and nanoparticle carriers
• Develop quantitative readouts of transcytosis and intracellular trafficking, and distinguish transport
from surface association
• Adapt models to disease-relevant genotypes, including patient-derived or gene-edited iPSC lines
• Analyze and present data to the Simmons Lab and to Synth-Med; contribute to internal reports,
regulatory-facing documentation, grant applications, and publications
• Mentor graduate and undergraduate students working on related projects
Required
• PhD in biomedical engineering, cell biology, neuroscience, pharmacology, or a related field
• Hands-on experience building and running Transwell BBB models, with demonstrated command of
barrier integrity measurement and troubleshooting
• Independent hiPSC culture experience.
• Strong quantitative data analysis and a track record of peer-reviewed publication
• Ability to work to project timelines in a collaborative, partly industry-facing setting
Preferred
• Prior work on lysosomal storage disorders
• Familiarity with nanoparticle or liposomal drug delivery and associated characterization methods
• Experience with receptor-mediated transcytosis approaches
• Microfluidic or organ-on-chip barrier models
• Confocal and live-cell imaging, image quantification
• Experience with electronic lab notebooks and structured documentation practices suitable for
regulatory submissions
• Experience with co-culture assays and the practical problems that come with them — media
compatibility, seeding order, timing, and controls
What we offer
• A project with a clear translational endpoint and a direct line to program decisions
• Access to the Simmons Lab's microfabrication, imaging, and stem cell facilities, plus the wider
Toronto research ecosystem
• Mentorship from both an academic PI and an industry R&D team, with exposure to preclinical
development and regulatory strategy
• Support for conference travel and professional development
• Publication rights on project outcomes, subject to standard IP review
How to apply
For your application:
please complete this form:
https://forms.office.com/r/YeY66vA3BE
and upload a cover letter and CV here:
https://synthmed.sharepoint.com/:f:/s/Hiring/IgDZWinpfd1vQ5ojXU6VO2t_AaXXf_W9wKPc0qEXZsLYwcU
Journal
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